Most Recent Publications
PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory disease. Kim YK, Kim YR, Wells KL, Sarbaugh D, Guney M, Tsai CF, Zee T, Karsenty G, Nakayasu ES, Sussel L. PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress. Diabetes. 2023 Nov 28:db230355. doi: 10.2337/db23-0355. Epub ahead of print. PMID: 38015772.
Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L. Genes Dev. 2023 Jun 1;37(11-12):490-504. doi: 10.1101/gad.350569.123. Epub 2023 Jun 26. PMID: 37364986.
Not the second fiddle: α cell development, identity, and function in health and diabetes. Brooks EP, Sussel L. J Endocrinol. 2023 Jul 11;258(2):e220297. doi: 10.1530/JOE-22-0297. PMID: 37171828.
Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. Diabetes Care. 2023 Jun 1;46(6):1112-1123. doi: 10.2337/dc23-0380. PMID: 37125948; PMCID: PMC10234745.
Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration. Kim YK, Walters JA, Moss ND, Wells KL, Sheridan R, Miranda JG, Benninger RKP, Pyle LL, O'Brien RM, Sussel L, Davidson HW. Mol Metab. 2022 Dec;66:101632. doi: 10.1016/j.molmet.2022.101632. Epub 2022 Nov 5. PMID: 36347424; PMCID: PMC9672421.
Leveraging the strengths of mice, human stem cells, and organoids to model pancreas development and diabetes. Lorberbaum DS, Sarbaugh D, Sussel L. Front Endocrinol (Lausanne). 2022 Oct 21;13:1042611. doi: 10.3389/fendo.2022.1042611. PMID: 36339450; PMCID: PMC9634409.
mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic β Cell Function. Moss ND, Sussel L. Front Genet. 2020 Sep 1;11:983. doi: 10.3389/fgene.2020.00983. eCollection 2020. PMID: 33088281
An Ultradian Notch in Beta-Cell Development. Pajvani UB, Sussel L. N Engl J Med. 2020 Jul 2;383(1):80-82. doi: 10.1056/NEJMcibr2001628. PMID: 32609988
Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification. Lorberbaum DS, Kishore S, Rosselot C, Sarbaugh D, Brooks EP, Aragon E, Xuan S, Simon O, Ghosh D, Mendelsohn C, Gadue P, Sussel L. Development. 2020 Jun 22;147(12):dev189977. doi: 10.1242/dev.189977. PMID: 32467243
Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Stem Cell Reports. 2020 Jun 9;14(6):1033-1043. doi: 10.1016/j.stemcr.2020.04.003. Epub 2020 May 7. PMID: 32386561
Animal Models of Pancreas Development, Developmental Disorders, and Disease. Lorberbaum DS, Docherty FM, Sussel L. Adv Exp Med Biol. 2020;1236:65-85. doi: 10.1007/978-981-15-2389-2_3. PMID: 32304069
A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development. Lorberbaum DS, Sussel L. Dev Cell. 2020 Mar 23;52(6):681-682. doi: 10.1016/j.devcel.2020.02.018. PMID: 32208161
The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function. Singer RA, Arnes L, Cui Y, Wang J, Gao Y, Guney MA, Burnum-Johnson KE, Rabadan R, Ansong C, Orr G, Sussel L. Cell Metab. 2019 Dec 3;30(6):1091-1106.e8. doi: 10.1016/j.cmet.2019.09.013. Epub 2019 Oct 10. PMID: 31607563
Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1. Romer AI, Singer RA, Sui L, Egli D, Sussel L.Diabetes. 2019 Dec;68(12):2259-2271. doi: 10.2337/db19-0117. Epub 2019 Sep 13. PMID: 31519700
β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes. Hudish LI, Reusch JE, Sussel L. J Clin Invest. 2019 Oct 1;129(10):4001-4008. doi: 10.1172/JCI129188
FISHing for β Cells. Hudish LI, Lorberbaum DS, Sussel L.Dev Cell. 2019 Jan 7;48(1):7-8. doi: 10.1016/j.devcel.2018.12.007. PMID: 30620904
Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes. Font-Cunill B, Arnes L, Ferrer J, Sussel L, Beucher A. Front Genet. 2018 Nov 6;9:524. doi: 10.3389/fgene.2018.00524. eCollection 2018. PMID: 30459811